The Long Term Effects Of Colorectal Cancer - 1393 Words

A cancer diagnosis can bring most people to tears because it is thought of as an early death sentence. Colorectal cancer is the third most common type of cancer, inflicting over 1 million people every year and accounting for more than 600,000 deaths worldwide.1, 5 Patients with colorectal cancer concomitantly present with anemia.1, 2 In addition to the blood loss expected during surgery, anemic patients undergoing surgical resection of colorectal cancer are at increased need for perioperative blood transfusion.2 In the early 1980s, researchers began to question the long-term effects of perioperative blood transfusions administered to patients with cancer.3 A year later the first clinical study was conducted and showed untoward effects on cancer recurrence. Since then many studies have shown an increased morbidity and mortality and higher recurrence rate of cancer due to immunomodulation.3, 4, 5 Presented here is a case report of a patient recently diagnosed with colorectal cancer and right and left lobe liver masses. Case Report A 53-year old female (height: 157 cm, weight: 65 kg) with NKDA underwent a colonoscopy screening that revealed a mass in the right colon. Biopsies indicated high-grade adenocarcinoma. Staging CT scans indicated a IIIB, T3N1cM0 malignant tumor and also showed two resectable liver lesions, on right and left lobes. Medical history included asthma, diverticulosis, depression and anxiety. She also had a rectal adenoma removed during a colonoscopy inShow MoreRelatedEffects Of The Diagnosis Of Bowel Cancer915 Words   |  4 PagesGoldwasser (2009) accepted that being diagnosed with cancer comes as a terrible shock for most people and those affected may look back on the experience and remember it as all being a bit of a dream. Often they are given information that they are only able to take in part of what they are told. As the news sinks in and they are ready to talk about what is going to happen, the most important thing to remember is that it is their body they are discussing. Peop le must be allowed to make decisionsRead MoreDevelopment Of Drugs With High Potency And Inhibitory Activity1618 Words   |  7 Pagesmade testing specific sensitizing mutation necessary. (1) (EGFR) T790M mutation a successful example of a biomarker for non-small cell lung cancer (NSCLC) treatment with Osimertinib that gained a wide acceptance in clinical practice in Europe and US (), One question that needs to be asked, however, is whether testing for similar mutations in different cancer will be of clinical value. an unknown subpopulation of patients with CRC will have an activating EGFR mutation, such as L858R, which is thoughtRead MoreSymptoms And Treatment Of Patients With Colon Cancer1510 Words   |  7 PagesInterventional Therapy Nearly one-third of patients diagnosed with colon cancer have metastatic disease (disease that has spread to other parts of the body) (Colon Cancer Alliance 2015a). The most common site of spread is the liver (Colon Cancer Alliance 2015a). Patients with rectal cancer may also have metastatic disease that has spread to the liver. Ablation and embolization are interventional therapies directed at the liver to destroy cancer cells. Ablation This technique destroys tumors without removingRead MoreEssay On Intestinal Tumorigenesis1712 Words   |  7 Pagesvasodilation, edema and pain. Long-term inflammation can also occur and leads to a chronic state with conditions favorable for tissue damage and genomic lesions (1,2). Over time this genetic damage can lead to cancer. An example of chronic inflammation leading to cancer development can be seen in patients with ulcerative colitis. These patients have long-lasting inflammation and ulcers in the lining of their large intestine and rectum and are more likely to develop colorectal cancer (3). In these types ofRead MorePathological Correlation Report- Jack s Case3052 Words   |  13 Pageslower GI bleed with results from the per rectum examination confirming a colonic source. The cause of the bleed as well as other symptoms displayed may be as a result of several conditions such as Crohn’s disease, haemorrhoids, anal fissure, polyps, cancer, stomach and duodenal ulcer s/peptic ulcer, gut infections which may cause bloody diarrhoea, angiodysplasia e.t.c. (). However, further look into the family history shows that his grandfather died from colonic carcinoma at the age of 45. This narrowsRead MoreEffects Of Alcohol During Athletic Activities816 Words   |  4 PagesAlcohol has many negative effects on those who participate in athletic activities. The NCAA warns â€Å"Excessive alcohol can lead to loss in balance and coordination, reduced reaction time, and increased appetite. The decline in cognitive function can lead to an increase in sports-related injuries† (SCAN Registered Dietitians, 2013). This only scratches the surface of negative effects. Drinking alcohol prior to an athletic event often leads to dehydration which causes problems such as â€Å"increased coreRead MorePrevention Of Cancer And Early Detection1293 Words   |  6 PagesOctober is Breast Cancer Awareness month and it is just timely that I would like to delve into one m ost of the debilitating chronic diseases worldwide. Cancer affects millions of people in all ages, various races, and all walks of life. all forms of media, prevention of cancer and early detection has been propped up to increase public awareness and improve the quality of life of those people suffering from this serious condition. The aforementioned topic has caught my eye especially recentlyRead MoreClimate Change and Rising Cancer Rates Essay1688 Words   |  7 PagesHow does climate change increase people’s probabilities of developing cancer? Global warming, a rise in the average global temperature, is a form of climate change that has caused glaciers to melt, acid rain to form, and sea levels to rise killing both vegetation and animals. What you probably don’t know is that climate change is killing humans too. â€Å"Cancer is the leading cause of death worldwide and accounted for 7.6 million deaths in 2008† , which is equivalent to the population of Bulgaria. GlobalRead MoreCancers Presence in the World1598 Words   |  6 PagesCancer represents a significant cause of morbidity and mortality worldwide, accounting for 8.2 million deaths in 2012. According to the last World Health Organization report, It reveals that it is expected that the global burden of cancer will rise from an est imated 14 million new cases per year in 2012 to 22 within the next two decades because of the aging and growth of the world population and an increasing adoption of cancer-causing behaviors. Lung, liver, stomach, colorectal and breast cancersRead More Genetic Testing and the US Healthcare System Essay2446 Words   |  10 Pagesto the study of relatively rare single-gene or chromosomal disorders. But as result of advances in molecular medicine, genetics is now able to provide information about more common and accordingly more costly diseases such as Alzheimer’s disease, cancer, and coronary artery disease. It is the predictive ability of genetic tests for these diseases that makes them especially intriguing in adopting a preventive medicine approach and reducing overall healthcare expenditures.   Ã‚  Ã‚  Ã‚  Ã‚  In Alzheimer’s disease

Analysis Of The Article Withdrawal From Trans Pacific...

In the article, â€Å"Withdrawal from Trans-Pacific Partnership, TPP shifts U.S. role in world economy† by Ylan Mui (2017), the author discusses US exit from the TPP, and its impact on world economy. According to Mui, Trump’s cancellation of the agreement for a comprehensive trade deal with Asia began shifting the role of the US in in the world’s economy. The departure leaves a gap for other potential countries to flex their economic muscle. The departure is also viewed as a symbolic move, aimed at showing that the president’s hard-hitting talk on trade during his campaign will continue to his new administration. Mui continues to explain that the action to departure from the TPP came at a time China and other nations across the globe with a†¦show more content†¦Pulling out of the TPP raised significant questions about the reliability of the US, and left most of the US trading partners and allies in the lurch. On the other hand, the deal created an open gap placing China in a position to make as strategic move. Mui continues to explain that this exit put china in the best position to take advantage of the situation that could lead to significant loss for the US. The Chinese government could sign a deal with the Japanese government, which could consequently jeopardize up to $5 billion in American jobs and US exports. Additionally, the move places China in a position of great authority in that it could command the terms of global trade (Mui, 2017). Mui continues to argue that the US could save the situation by signing bilateral deals with the individual countries involved in the TPP especially Vietnam and Japan. However, there is a need to make a swift move since China is aggressively seeking to lock in trade contracts with most of the same countries that were involved in the signing of the TPP. Trump had also vowed to renegotiate the NAFTA (North American Free Trade Agreement), which significantly vital to the economic relationship between Canada, US, and Mexico. According to Mui, Mexico’s president, Pena Nieto continues to assert that his country would be looking to diversify its political and trading partners during the Trump’s era so that it could stop relying heavily on the US government. The author continues to

The Body’s Response To Stress And How Do We Deal With It Free Essays

Introduction Stress is a psychological and physical response of the body that occurs whenever we must adapt to changing conditions. And a stressor is the stimulus that brings about the stress response. For example, if you are scared of flying, airports may be a stressor for you. We will write a custom essay sample on The Body’s Response To Stress And How Do We Deal With It or any similar topic only for you Order Now Hypothalamic Pituitary Adrenal Axis (HPA) The stress response begins in the brain in an area called the hypothalamus, this is the point at which the perception of stress by higher brain centres begins a major physiological change in the body, it does this by stimulating 2 biological mechanisms. The first is called the Hypothalamic Pituitary Adrenal system (HPA). When a stressor is detected, the higher brain centre send signals to hypothalamus telling it to ready the body for action. The hypothalamus does this by communicating with another part of the brain called the pituitary gland, stimulating it to release adrenocorticotrophic hormone (ACTH). ACTH is detected in the bloodstream by the adrenal cortex, and in response it releases further hormones called the corticosteroids. There are a number of corticosteroids each having specific effects on the body, like causing liver to release glucose, fatty acids and cholesterol for extra energy needed during stress. When the corticosteroids are detected by the brain it has the effe ct of switching off the stress response. Sympathetic Adrenalmedullary Axis (SAM) For the sympathetic adrenal medullary axis (SAM), when the hypothalamus activates the sympathetic nervous system, which is a part of the autonomic nervous system, it stimulates a gland in the body called the adrenal medulla to release 2 hormones called adrenaline and noradrenaline into the bloodstream, these hormones have wide-ranging effects but mainly to increase blood pressure and heart rate. Seyle’s General Adaption Syndrome Han Selye(1940) developed a theory which has helped us understand how and why stress leads to illness. He subjected animals to a variety of stressors such as injection, poison or extreme temperature and found that a similar pattern of physical responses could be observed, and divided them into three different stages. At stage 1 which is the alarm stage, stressor is perceived, HPA and SAM are activated, heart rate and blood pressure therefore increase.Stage 2, the resistant stage, the level of stress-related hormones and bodily arousal are remaining high n finally, at the final exhaustion stage, long period of stress (chronic stress) eventually exhaust the body’s defense system and its ability to maintain high levels of circulating stress hormones, stress related illness may develop. There has been an increasing body of evidence supporting a relationship between long-term stress and cardiovascular disease, 2 of the biggest risks are high blood pressure and coronary heart d isease. Kiecolt- Glaser’s Exam Study Research on a wide variety of stressors has shown that stress can reduce the effectiveness of the immune system. Kiecolt- Glaser et al (1984) has done an experiment on stress and the immune system. The aim of the experiment is to see whether external stress can have an impact on the immune system. They did it by collecting samples of 75 medical students on 2 different occasions. First, blood samples was taken at one month before their examinations, which is a relatively low stress time and secondly, during the examinations. The researchers looked at each of the blood samples and calculate the natural killer cell content. The more natural killer cells, the more efficient the immune system. Finally they found that the blood samples taken during the exams were much lower in NK cells than the samples taken a month earlier. One of the drawbacks of this experiment is that it had a causality problem, we cannot conclude that the stress caused the reduction in the immune system. Moreover, there may be a sampling bias, the participants are students n it is possible that they may respond to stress differently than some other types of people. However, being a natural experiment this study has high validity and there are likely to be few or no demand characteristics, though control of extraneous variables was not possible. Problem-focused method of coping The methods of coping with stress can be distinguished into emotion-focused and problem-focused methods of coping. The problem focused way deal with stress by treating it as a problem and actively engage with it. This includes anticipatory coping by gaining information about what makes us stressed and develop a plan of action to help us deal with it, and seeking social suport, pit means identify events in the environment that are either causing or likely to trigger stress, then we can take practical steps to avoid or better deal with it. SIT, the stress inoculation training is developed by Meichenbaum (1972) , its a psychological method of dealing with stress by restructuring how we think about events. First the client is encouraged to reappraise stress, the therapist discusses the nature of stress with the client and explores stressful experiences that the client had in the past. Secondly the client is taught various ways of coping with stress, these would be quite specific and inc lude general strategies such as relaxation. In the final phase clients are encouraged to apply their training to the real world. The stressors may be graded and gradually increase in intensity. Meichenbaum then wanted to investigate how effective his own SIT treatment was. So he studied anxious pre-exam students and placed them in three different conditions which are 8 weeks of SIT, 8 weeks of systematic desensitisation, and the controlled group which had no therapy at all. The efficiency of SIT was evaluated through exam performance and self reports by participants. So simply, if the students felt it has been sucessful and they performed well in exams, SIT was judged to have worked. Finally he found that the SIT group gave the most positive self-reports and outperformed the other students in exam. Some drawbacks of this study is that self-reports are not necessarily reliable , just because a person feels that something has not worked does not mean they receive no benefits from it. Moreover the study does not address â€Å"optimum treatment period†, so we cannot be sure which of the method is best, only that SIT worked better than systematic desensitisation if a treatment period of 8 weeks is used. Although SIT is neither a quick, easy or cheap method to mange stress, it is flexible and the benefits of it can be long term. The emotion-focused way of coping The emotion-focused method is one that provides stressed person with relief from their symptoms. Some of the techniques are defence mechanisms, which is a way of blocking out the stress, or they may choose to reappraise it, which means simply changing the way they feel about the situation. Drugs is also the common physiological method to use. The most widely used prescribed drugs today are benzodiazepines and beta-blocker. They are quick acting, but do not treat the cause of problem, they may also have side effects n cause addiction too. Conclusion In conclusion, the problem focused strategies aim to change, alter or even remove the stressful problem, while emotion-focused aim to control or regulate the feelings a person is having. It has no a very satisfying answer of which one is better than the other, each has its strengths n weaknesses and each works best in different situations. Different people with different personalities and characteristics can react differently to stress, so which method of coping to choose is depend on numbers of factors, gender, age, and even wealth may also matter! Reference: NHS http://www.nhs.uk/Conditions/Stress/Pages/Introduction.aspx New 2008 AQA ‘A’ Specification AS Level Psychology, Nigel Holt and Rob Lewis, Crown House Publishing Limited Coping with stress http://www.helpguide.org/mental/stress_management_relief_coping.htm How to cite The Body’s Response To Stress And How Do We Deal With It, Essay examples